Efficiency of developed solid state bioreactor ‘FERMSOSTAT’ on cellulolytic and xylanase enzymes production

FERMSOSTAT is a developed laboratory scale solid state fermenter. It is a horizontal stirrer drum bioreactor with about 70 L capacities. The fermenter is made of stainless steel which is anti-corrosive and non-toxic to the process organism. The fermenter is equipped with sets of control systems for temperature, agitation, aeration and also outlets for substrate sampling as well as inlets for inoculation and substrate additions. The uniqueness of this FERMSOSTAT system is its ability to carry out in situ substrate sterilization and extraction of enzymes at the end of SSF process. Moreover, the mixing system provided by FERMSOSTAT can be performed either full or half mixing as well as forward or reverse mixing. Furthermore, the mixing can be programmed to run at certain agitation rate and time interval during the fermentation process to prevent or reduce damage to the fungus mycelia. FERMSOSTAT is a developed SSF bioreactor and not an improvement of any existing one. The performances of FERMSOSTAT have been evaluated. Under optimum solid state fermentation conditions, about 63.4, 397 and 3.21 U/g of CMCase, xylanase and FPase activities were detected, which were higher compared to the tray system

Direct CP, T and/or CPT violations in the K^0-\bar{K^0} system - Implications of the recent KTeV results on 2π2\pi decays -

The recent results on the CP violating parameters Re(e'/e) and \Delta\phi = \phi_{00}-\phi_{+-} reported by the KTeV Collaboration are analyzed with a view to constrain CP, T and CPT violations in a decay process. Combining with some relevant data compiled by the Particle Data Group, we find Re(e_2-e_0) = (0.85 +- 3.11)*10^{-4} and Im(e_2-e_0) = (3.2 +- 0.7)*10^{-4}, where Re(e_I) and Im(e_I) represent respectively CP/CPT and CP/T violations in decay of K^0 and \bar{K^0} into a 2\pi state with isospin I.Comment: 7 pages, No figure

Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe

Kinetochores in multicellular eukaryotes are usually associated with heterochromatin. Whether this heterochromatin simply promotes the cohesion necessary for accurate chromosome segregation at cell division or whether it also has a role in kinetochore assembly is unclear. Schizosaccharomyces pombe is an important experimental system for investigating centromere function, but all of the previous work with this species has exploited a single strain or its derivatives. The laboratory strain and most other S. pombe strains contain three chromosomes, but one recently discovered strain, CBS 2777, contains four. We show that the genome of CBS 2777 is related to that of the laboratory strain by a complex chromosome rearrangement. As a result, two of the kinetochores in CBS 2777 contain the central core sequences present in the laboratory strain centromeres, but lack adjacent heterochromatin. The closest block of heterochromatin to these rearranged kinetochores is ∼100 kb away at new telomeres. Despite lacking large amounts of adjacent heterochromatin, the rearranged kinetochores bind CENP-ACnp1 and CENP-CCnp3 in similar quantities and with similar specificities as those of the laboratory strain. The simplest interpretation of this result is that constitutive kinetochore assembly and heterochromatin formation occur autonomously

On the stability of black hole event horizons

In this work we study a {\it gedanken} experiment constructed in order to test the cosmic censorship hypothesis and the second law of black hole thermo-dynamics. Matter with a negative gravitating energy is imagined added to a near extremal $U(1)$-charged static black hole in Einstein-Maxwell theory. The dynamics of a similar process is studied and the thermo-dynamical properties of the resulting black hole structure is discussed. A new mechanism which stabilizes black hole event horizons is shown to operate in such processes.Comment: 16, grammatical errors corrected and two references adde

Forex trading prediction using linear regression line, artificial neural network and dynamic time warping algorithms

Forex prediction has become a challenging task in the Forex market since the late 1970s due to uncertainty movement of exchange rates.In this paper, we utilised linear regression equation to analyse the historical data and discover the trends patterns in Forex.These trends patterns are modeled and learned by Artificial Neural Network algorithm, and Dynamic Time Warping algorithm is used to predict the near future trends.Our experiment result shows a satisfactory result using the proposed approach

The metallic state in disordered quasi-one-dimensional conductors

The unusual metallic state in conjugated polymers and single-walled carbon nanotubes is studied by dielectric spectroscopy (8--600 GHz). We have found an intriguing correlation between scattering time and plasma frequency. This relation excludes percolation models of the metallic state. Instead, the carrier dynamics can be understood in terms of the low density of delocalized states around the Fermi level, which arises from the competion between disorder-induced localization and interchain-interactions-induced delocalization.Comment: 4 pages including 4 figure

Lyapunov Potential Description for Laser Dynamics

We describe the dynamical behavior of both class A and class B lasers in terms of a Lyapunov potential. For class A lasers we use the potential to analyze both deterministic and stochastic dynamics. In the stochastic case it is found that the phase of the electric field drifts with time in the steady state. For class B lasers, the potential obtained is valid in the absence of noise. In this case, a general expression relating the period of the relaxation oscillations to the potential is found. We have included in this expression the terms corresponding to the gain saturation and the mean value of the spontaneously emitted power, which were not considered previously. The validity of this expression is also discussed and a semi-empirical relation giving the period of the relaxation oscillations far from the stationary state is proposed and checked against numerical simulations.Comment: 13 pages (including 7 figures) LaTeX file. To appear in Phys Rev.A (June 1999

Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert.

Benznidazole is the main drug used to treat Trypanosoma cruzi infections. However, frequent instances of treatment failure have been reported. To better understand potential resistance mechanisms, we analysed three clones isolated from a single parasite population that had undergone benznidazole-selection. These clones exhibited differing levels of benznidazole-resistance (varying between 9 and 26-fold), and displayed cross-resistance to nifurtimox (2 to 4-fold). Each clone had acquired a stop-codon-generating mutation in the gene which encodes the nitroreductase (TcNTR) that is responsible for activating nitroheterocyclic pro-drugs. In addition, one clone had lost a copy of the chromosome containing TcNTR. However, these processes alone are insufficient to account for the extent and diversity of benznidazole-resistance. It is implicit from our results that additional mechanisms must also operate and that T. cruzi has an intrinsic ability to develop drug-resistance by independent sequential steps, even within a single population. This has important implications for drug development strategies

On the Khalfin's improvement of the LOY effective Hamiltonian for neutral meson complex

The general properties of the effective Hamiltonian for neutral meson system improved by L.A. Khalfin in 1980 are studied. It is shown that contrary to the standard result of the Lee--Oehme--Yang (LOY) theory, the diagonal matrix elements of this effective Hamiltonian can not be equal in a CPT invariant system. It is also shown that the scalar product of short, $|K_{S}>$, and long, $|K_{L}>$, living superpositions of neutral kaons can not be real when CPT symmetry is conserved in the system under considerations whereas within the LOY theory such a scalar product is real.Comment: LaTeX2e, 25 pages, new comment and references adde